Methyllevallorphanium salts having peripheral opiate antagonisti

Details Methyllevallorphanium salts having peripheral opiate antagonisti Methyllevallorphanium salts having peripheral opiate antagonisti

1986-02-04

1988-04-05

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 74, A61K 31485, C07D22128

Patent

active

047359471

ABSTRACT:
Methyllevallorphanium salts having peripheral antagonistic activity of formula ##STR1## wherein Y.sup.n(-) represents the anion a pharmaceutically acceptable acid other than halogen and n represents the number of negative charges of said anion; a process for their preparation by exchange of the halogen ion with the Y.sup.n(-) anion; and pharmaceutical compositions containing them as active ingredients.

REFERENCES:
patent: 3101339 (1963-08-01), Zeile et al.
patent: 4176186 (1979-11-01), Goldberg et al.
patent: 4489079 (1984-12-01), Giudice et al.
Kobylecki et al., J. Med. Chem., vol. 25(11), pp. 1278-1280, (11/82).
Bianchetti et al., Life Sci., vol. 31(20-21), pp. 2261-2264, (1982).
Bianchetti et al., Life Sci., vol. 33(suppl. 1), pp. 415-418, (1983).
Dragonetti et al., Life Sci., vol. 33(suppl. 1), pp. 477-480, (1983).
Barton et al., ed., "Synthetic Analgesics", Pergamon Press (1974), part II, p. 48.
Koczka et al., Chemical Abstracts, vol. 67, 11621n, (1967).
Hellerbach et al., Helv. Chim. Acta, vol. 39(49) fasc II, pp. 429-440, (1956).
Notarnicola et al., Chemical Abstracts, vol. 100, 17504y, (01/16/84).
International Series of Monographs in Organic Chemistry, Barton et al., General Editors, vol. 8, Synthetic Analgesics, Part IIA, Morphinans, by Hellerbach et al., Pergamon Press, N.Y., (1966), pp. 3-112.

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