Human serum plasminogen activator

Details Human serum plasminogen activator Human serum plasminogen activator

1978-03-30

1981-01-13

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

260112B, 424101, C12N 948, A61K 3516

Patent

active

042450519

ABSTRACT:
A plasminogen proactivator and a corresponding activator has been isolated from mammalian and avian, especially human, plasma which is characterized within a given species as a single, electrophoretically and immunologically homogeneous protein. The activator acts as a catalyst to initiate fibrinolytic activity in plasma and is therefore useful in controlling clotting which occurs, e.g. in venous thrombosis or arterial occulsion, and in diagnosing conditions which predispose to thromboembolic phenomena. The proactivator has a long useful in vivo half life and can be used to provide a reservoir for maintaining the fibrolytic potential of blood.

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Laemmli, Nature, vol. 227, (1970), pp. 680-685.
Converse et al., Science, vol. 189, (1975), pp. 469-472.

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