Heat treatment of lyophilized blood clotting factor VIII concent

Details Heat treatment of lyophilized blood clotting factor VIII concent Heat treatment of lyophilized blood clotting factor VIII concent

1982-05-13

1984-06-26

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3516

Patent

active

044565909

ABSTRACT:
A method for treating blood products to eliminate hepatitis virus present therein is disclosed. Blood products treated according to the method are first lyophilized and then subjected to heat for a period of time sufficient to inactivate the hepatitis virus. At the conclusion of the heating step the blood product can be reconstituted using sterile water or a like diluent. No adverse effects on blood product activity following treatment have been observed. The method has special applicability to blood plasma fractions such as Factor VIII, Factor IX and fibrinogen.

REFERENCES:
patent: 3041242 (1962-06-01), Barr et al.
patent: 3100737 (1963-08-01), Auerswald et al.
patent: 3859168 (1975-01-01), Barth et al.
patent: 4250139 (1981-02-01), Luck et al.
patent: 4297344 (1981-10-01), Schwinn et al.
patent: 4327086 (1982-04-01), Fukushima et al.
patent: 4347259 (1982-08-01), Suzuki et al.
De Flora, J. of Immunol, vol. 120, No. 1, (Jan. 1978), pp. 40-45.
De Flora, Chem. Abst., vol. 88, (1978), p. 61,042d.
Kaplan, "The Heat Inactivation of Vaccinia Virus," J. Gen. Microbiol., 18:58-63, (1958).
Cowdery et al., "Stability Characteristics of Freeze-Dried Human Live Virus Vaccines," Develop. Biol. Standard, 36:297-303, (1977).
Beardmore et al., "Preservation of Influenza Virus Infectivity by Lyophilization," Applied Microbiology, 16(2):362-365, (1968).
Greiff et al., "Stability of Suspensions of Influenza Virus Dried to Different Contents of Residual Moisture by Sublimation in Vacuo," Applied Microbiology, 16(6):835-840, (1968).
Plowright et al., "Studies on Rinderpest Culture Vaccine. III. Stability of the Lyophilised Product," Res. Vet. Sci., 11:71-81, (1970).
Apostolov et al., "Selective Inactivation of the Infectivity of Freeze-Dried Sendai Virus by Heat," Cytobiology, 10:255-259, (1973).
Schable et al., "Stability of a Reference Panel of Lyophilized Hepatitis B Antigens and Antibodies," J. Biol. Standardization, 7:293-299, (1979).
Berge et al., "Preservation of Enteroviruses by Freeze-Drying," Applied Microbiology, 22(5):850-853, (1971).
Grieff et al., "An Accelerated Storage Test for Predicting the Stability of Suspensions of Measles Virus Dried by Sublimation in Vacuo," J. Immunology, 94(3):395-400, (1965).
Kraft et al., "Lyophilization of Poliomyelitis Virus. Heat Inactivation of Dry MEFl Virus," Proc. Soc. Exp. Biol. Med., 9:306-309, (1954).
Scatchart et al., "Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation. IV. A Study of the Thermal Stability of Human Serum Albumin," J. Clin. Invest., 23:445-453, (1944).
Sirridge, Laboratory Evaluation of Hemostatis, Second Edition, Lea & Febiger, Philadelphia, 1974, pp. 7-8.
Bangham et al., "Stability of Some Clotting Factors in Freeze-Dried Factor VIII-Reference Plasma and Concentrate," Chem. Abstracts, 76:22760u, (1972).
Brozovic et al., "Stability of Prothrombin and Factor VII in Freeze-Dried Plasma," J. Clin. Path., 24:690-693, (1971).
Plasma Products; Use and Management. A Technical Workshop, Kolins et al., (eds.), The Committee on Technical Workshops, American Association of Blood Banks, Anaheim, CA, (1982).
Gerety et al., "Plasma Derivatives and Viral Hepatitis," Transfusion, 22(5):347, (1982).
Tabor et al., Infectious Complications of Blood Transfusion, Academic Press, New York, 1982, pp. 6, 24.
Aronson et al., "Historical and Future Therapeutic Plasma Derivatives (Epilogue)," Seminars in Thombosis and Hemostasis, VI(2):121-123, (1980).
Rosenberg et al., "Thermoinactivation of Virus of Botkin's Disease (Hepatite Virus) in Dry Fibrinogen and Albumin Preparations," XII International Congress on Blood Transfusion Abstracts, MIR Publishers, Moscow, 1969, pp. 473-475.
Soulier et al., "Prevention of Virus B Hepatitis (SH Hepatitis)," Amer. J. Dis. Child, 123:429-434, (1972).
Paine et al., "Human Albumin Infusions and Homologous Serum Jaundice," JAMA, 150(3):199-202, (1952).
Havens et al., "Properties of the Etiologic Agent of Infectious Hepatitis," Proc. Soc. Exp. Biol. Med., 58:203-204, (1945).
Bertrand et al., "Clinical Investigations with a Heat-Treated Plasma Protein Fraction-Plasmanate," Vox Sang., 4:385-402, (1959).
Roberts et al., "Post-Transfusion Hepatitis Following the Use of Prothrombin Complex Concentrates," Thrombos, Diathes. Haemorrh., (Stuttg.), 33:610-616, (1975).
Tabor et al., "Removal of Hepatitis-B-Virus Infectivity from Factor-IX Complex by Hepatitis-B Immune-Globulin," The Lancet, pp. 68-70, Jul. 12, 1980.
Allen et al., "Homologous Serum Jaundice and Its Relation to Methods of Plasma Storage," Jama 144(13):1069-1074, Nov. 25, 1950.
Funakoshi et al., "Injectable Inactivated Vaccine Against Hepatitis B," Chem Abstracts, 89:65254t, (1978).
Schwinn et al., "Blood Coagulation Factors," Chem. Abstracts, 94:36335t, (1981).

Affiliated with

Also associated with

Rating

Heat treatment of lyophilized blood clotting factor VIII concent does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heat treatment of lyophilized blood clotting factor VIII concent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heat treatment of lyophilized blood clotting factor VIII concent will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2232089