Process for the preparation of compounds with antiulcer action

Details Process for the preparation of compounds with antiulcer action Process for the preparation of compounds with antiulcer action

1990-10-16

1992-06-02

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549435, 549495, 549440, 549442, 548342, 564105, C07D23364, C07D31756

Patent

active

051188139

ABSTRACT:
For the preparation of compounds such as ranitidine, niperotidine and cimetidine a urea of the formula:

REFERENCES:
patent: 4157340 (1979-06-01), Crenshaw
Synthesis, No. 5, May 1985 (Stuttgart, DE), F. Moimas et al.; "A New Approac Approach To 1-Nitro-2, 2-Bis[Alkyl-or Aryl-Amino]Ehtylenes: A New Synthesis of Ranitidine", pp. 509-510, (whole document).
Chemical Abstracts, vol. 94, No. 7, 16 Feb. 1981, (Columbus, Ohio USA), see page 529, Abstract 46806m, & ES, A, 477817 (A. L. Palomo Coll et al.) 1 Jul. 1980.
Chemical Abstracts, vol. 105, No. 13, 29 Sep. 1986, (Columbus, Ohio U.S.A.), I. Kraemer et al.; "H.sub.2 -Antihistiminics. 29. Synthesis and H.sub.2 -Antagonist Activity of mono-and bis-functionalized hydrazines", see page 671, Abstract 11968p & Pharm. Ztg. 1985, 130(33), 2062-6.

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