Use of synthetic peptides to disrupt the cytoskeleton

Details Use of synthetic peptides to disrupt the cytoskeleton Use of synthetic peptides to disrupt the cytoskeleton

1993-08-25

1996-06-18

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 530324, 530326, 530327, 530328, 530350, 530357, 4352402, 43524021, 43524023, 43524024, 43524025, A61K 3810, A61K 3818

Patent

active

055277730

ABSTRACT:
Synthetic peptides corresponding to different regions of the human keratin 1 chain can disassemble preformed keratin intermediate filaments or inhibit filament assembly both in vitro and in vivo. The disruption of keratin filaments may have therapeutic applications in the treatment of epithelial abnormalities.

REFERENCES:
Steinert et al., J. Biol. Chem., vol. 260, No. 11 Issue of Jun. 10, pp. 7142-7149 (1985).
Steinert et al., J. of Investigative Dermatology, vol. 100, p. 500 (1993).
Johnson et al., Proc. Natl. Acad. Sci. USA, vol. 82, pp. 1896-1900, Apr. 1985.

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