Preparation of fluorinated methyl aminoalkanoic acids and novel

Details Preparation of fluorinated methyl aminoalkanoic acids and novel Preparation of fluorinated methyl aminoalkanoic acids and novel

1980-07-21

1982-10-12

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

560161, 564 90, 564187, 564215, 564279, 564509, C07C 8726, C07D20948

Patent

active

043538282

ABSTRACT:
Fluorinated alkenylamines of the Formula V ##STR1## wherein n represents 0, 1, 2 or 3; R.sub.1 represents hydrogen or C.sub.1 -C.sub.10 alkyl and Y represents (a), when n represents O, CH.sub.2 F, (b), when n represents 1, CH.sub.2 F or CHF.sub.2, or (c) when n represents 2 or 3, CH.sub.2 F, CHF.sub.2 or CF.sub.3 are novel process intermediates. They are obtained by hydrolysis and subsequent reduction of the corresponding alkenyl fluorinated methyl ketimine magnesium halides, which are novel compounds resulting from reaction of the corresponding alkenyl magnesium halides with the corresponding fluorinated acetonitriles. The fluorinated alkenylamines of Formula V are oxidized while the amino group is protected to provide, after removal of the amine protecting group, the corresponding fluorinated methyl aminoalkanoic acids which are useful pharmacological or anti-bacterial agents.

REFERENCES:
patent: 3320277 (1967-05-01), Mehta et al.
patent: 3478100 (1969-11-01), Gale

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