Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-10-21
1992-06-02
Friedman, S. J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546167, A61K 3147, C07D 4100
Patent
active
051186900
ABSTRACT:
The invention concerns a method for treating pain and/or CNS disorders characterized in that the method uses a compound which acts selectively as an antagonist of gamma aminobutyric acid (GABA) at GABA autoreceptors relative to GABA.sub.A receptors.
REFERENCES:
patent: 4622329 (1986-11-01), Bernath et al.
patent: 4666918 (1987-05-01), Ivanova et al.
Yamoto et al, Yakugaki Zasshi 87(9):1083-1088, 1967, Synthesis of 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline derivatives.
Sheykova & Nikolova. Bull. Inst. Physiol. VII: 243-252, 1964, Pharmacological activity of some analogs of papaverine, II. Communication. [see also Chem Abstracts 62:16784, 1965.]
Gray et al, J. Med. Chem. 32(6): 1242-1248. Phencyclidine-like effects of tetrahydroisoquinolines & related compounds.
Inwegen et al. Biochem. Pharmacol. 28:1307-1312, 1979, Dihydro- & tetrahydroisoquinolines as inhibitors of cyclic nucleotide phosphodiesterases from dog heart.
Translation of --Yakugaku Zasshi 83:1048 (1963).
Jap. J. Pharmacol. 17, 143 (1967), Yoshio Iwasawa et al.
J. Heterocycl. Chem. 4(4) 469 (1967), Wilhelm Wenner et al.
C. A. 68:10492g, Bisaku Yamato et al.
C.A. 72:66846.
C.A. 69:106,573d.
C.A. 73:25266m, Seeger et al.
Chem. Ber. 103:1674 (1970).
C.A. 79:834296, Kigazawa et al.
C.A. 82:4441k, Shamma M.
C.A. 100:22956b, Piper Ian M. et al.
C.A. 100:34749z.
J. Chem. Soc. Perkins Trans I 1985(2), 275, Barker et al.
C.A. 30:8224(6).
C.A. 49:5495b.
Iav. Inst. Fiziol. Bulgar Akad Nauk 7:243 (1964)--plus translation C.A. 62:16873h.
J. Chem. Soc. 1955, 430.
Agr. Biol. Chem. 39(2):547 (1975) Morita et al.
Eur. J. Pharmacol. 82:131 (1982), Pearce et al.
Nature 280:514 (1979).
Neuropharmacol 27(10) 1003 (1988), Ennis et al.
Neuropharmacol: 25(2) 175 (1985), Rastogi et al.
C.A. 52:15596h.
(C.A. 74:141571b)--See Japanese Patent above (1983).
C.A. 59:7553.
C.A. 60:10732h (Yakugaku Zasshi 53:1048 (1963)).
C.A. 58:11327g.
Minchin Michael C. W.
White Alan C.
White John F.
Friedman S. J.
John Wyeth & Brother Limited
Milowsky Arnold S.
LandOfFree
Pharmaceutical tetrahydroisoquinolines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical tetrahydroisoquinolines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical tetrahydroisoquinolines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2228602