Insulinotropic hormone

Details Insulinotropic hormone Insulinotropic hormone

1990-06-01

1992-06-02

Doll, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514866, 530308, 530324, A61K 3702, A61K 3728, C07K 710, C07K 734

Patent

active

051186667

ABSTRACT:
Derivatives of glucagon-like peptide I (GLP-1) have been found to have insulinotropic activity. The invention pertains to such derivatives, and to the use of such derivatives as a potential therapy for Diabetes Mellitus.

REFERENCES:
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Schmidt et al., Diabetologia 28=704-707 (1985).
Bell et al., Nature, 302=716-718 (1983).
Andrews et al., J. Biol. Chem. 260=3910-3914.
Houghten, R. A. et al., Biotechniques 4:522-524, 526, 528 (Jul. 1986).
Meienhofer, J., In: Peptides 1984, Ragnarsson, U. (ed.) Almqvist & Wiksell International, Stockholm (1984).
Sarson, D. L. et al., Diabetologia 22:33 (1982).
Hauner, H. et al., Ann. Nutr. Metab. 32:282-288 (1989).
Ganong, W., Review of Medical Physiology, 9th Ed., Lange Medical Publications, Los Altos, CA (1979) pp. 257-276.
Drucker, D. J. et al., Proc. Natl. Acad. Sci. USA 84:3434-3438 (1987).
Mojsov, S. et al., J. Clin. Invest. 79:616-619 (1987).
Holst, J. J. et al., FEBS Lett. 211:169-174 (1987).
Kreymann, B. et al., The Lancet, Dec. 5, 1987, pp. 1300-1304.
Weir, G. et al., Diabetes 38(3):338-342 (Mar. 1989).
Gefel, D. et al., Endocrinology 126 (4):2164-2168 (1990).

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