Alpha-halomethyl derivatives of histamine and related compounds

Details Alpha-halomethyl derivatives of histamine and related compounds Alpha-halomethyl derivatives of histamine and related compounds

1979-03-01

1980-09-09

Raymond, Richard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424273R, 548337, C07D23364, C07D23366

Patent

active

042219140

ABSTRACT:
Novel halomethyl derivatives of amines of the following general structure ##STR1## wherein Y is FCH.sub.2 --, F.sub.2 CH-- or F.sub.3 C--; R is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or ##STR2## wherein R.sub.3 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; each of R.sub.1 and R.sub.2 is hydrogen, or a straight or branched lower alkyl group of from 1 to 4 carbon atoms and may be the same or different or R.sub.1 is hydrogen and R.sub.2 is fluorine; and pharmaceutically acceptable salts and individual optical isomers thereof.

REFERENCES:
patent: 3169971 (1965-02-01), Sletzinger et al.
patent: 3387031 (1968-06-01), Johnson et al.

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