Peptidyl-1-amino-2,4-diols

Details Peptidyl-1-amino-2,4-diols Peptidyl-1-amino-2,4-diols

1986-02-19

1988-02-16

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 514478, 560159, 564155, 530332, 530331, A61K 3165, A61K 3743, C07K 506, C07K 702, C07C12506, C07C10320

Patent

active

047255846

ABSTRACT:
The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is an N-protecting group; R.sub.1, R.sub.2, R.sub.3 and R.sub.5 are independently selected from loweralkyl or lipophilic or aromatic amino acid side chains; and R.sub.4 is hydrogen, loweralkyl, loweralkylmercapto or loweralkylsulfonyl.

REFERENCES:
patent: 4548926 (1985-10-01), Matsueda et al.
Chem. Letter, pp. 1041-1044, (1985).

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