Substituted chromanon-2-yl alkanols and derivatives thereof

Details Substituted chromanon-2-yl alkanols and derivatives thereof Substituted chromanon-2-yl alkanols and derivatives thereof

1984-05-29

1985-10-08

Love, Ethel G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31104

Patent

active

045461945

ABSTRACT:
This invention relates to substituted chromanon-2-yl alkanols and derivatives thereof, which are useful as leukotriene D.sub.4 (LTD.sub.4) inhibitors and therefore useful in the treatment of allergies, inflammatory conditions, and coronary vasoconstriction.

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Chem. Abstracts 69: 85967t.
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Michelassi et al., "Leukotrine D.sub.4 : A Potent Coronary Artery Vasoconstrictor Associated with Impaired Ventricular Contraction," Science, 217, 841-843 (1982).
Burke et al., "Leukotrienes C.sub.4, D.sub.4 and E.sub.4 : Effects on Human and Guinea-Pig Cardiac Preparations in Vitro," J. Pharmacol. and Exp. Therap., 221, 235-241 (1982).
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