Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1992-08-06
1994-06-21
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
1286532, 1286534, 436173, 324300, 324307, 324308, 424646, G01N 2408, A61K 3326, G01V 300
Patent
active
053226828
ABSTRACT:
The invention provides a specific measure of iron stores in vivo using magnetic resonance imaging. T.sub.2 relaxation times in both lower-to-mid field strength magnetic resonance imaging instruments and a higher field strength instrument is evaluated. T.sub.2 obtained at the higher field strength instrument is subtracted from T.sub.2 obtained at the lower field strength instrument. This difference, T, is then correlated with a quantitative measure of the iron stores in vivo in the scanned tissue. A two-dimensional or multidimensional map of the scanned tissue is then constructed on the basis of T to visually identify different tissue types as being normal or abnormal, either through a visual determination based on gray scales or a numeric comparison based on quantitative measure. The introduction of artificial or nonbiological substances as opposed to natural ferritin, is permitted for further diagnostic use by application of this methodology.
REFERENCES:
patent: 4477777 (1984-10-01), Gordon
patent: 4735796 (1988-04-01), Gordon
patent: 4789830 (1988-12-01), Stokar
patent: 4889125 (1989-12-01), Doddrell et al.
patent: 4889126 (1989-12-01), Doddrell et al.
patent: 4984574 (1991-01-01), Goldberg et al.
patent: 5072732 (1991-12-01), Rapoport et al.
Narayan, P. et al. Magn. Res. in Med. 11:209-220 (1989).
Neurohr, K J et al. Adv. Myocardiol. 6:158-193 (1985).
Evelhoch, J L Invest. New Drugs 7:5-12 (1989).
"Role of Iron and Ferritin in MR Imaging of the Brain: . . . ," Bizzi et al., Radiology 1990; 177:59-65.
"4-tesla sites initiate clinical MR studies," by Lori D' Agincourt, Product Development pp. 81-83, 87 & 104, Diagnostic Imaging Dec. 1991.
"Magnetic Resonance Imaging and Brain Iron . . . ," Burton P. Drayer, M.D., BNI Quarterly, vol. 3 No. 4, Fall 1987, pp. 15-30.
"MRI in basal ganglia diseases," D. Wimberger et al., J. Neural Transm (1991) [suppl] 133-140 .RTM. by Springer-Verlag 1991.
"Dashed Hopes for MR Imaging of the Head and Neck . . . ," Editorials from the Neuroradiology Section, Dept. of Radiology, Hospital of the University of Pennsylvania, Radiology 1991; 184:25-26.
"T.sub.2 -Relaxometry-A Critical Investigation . . . ," Thomas Tolxdorff et al., SMRM 1988, p. 33.
"T.sub.2 Values in the Human Brain: Comparison with Quantitative Assays of Iron and Ferritin.sup.1 " Julian C. Chen, M.D. et al. Radiology 1989, pp. 521-526.
"Field Strength in Neuro-MR Imaging: A Comparison of 0.5T and 1.5T" Clifford R. Jack, Jr., et al., Journal of Computer Assisted Tomography, vol. 14, No. 4, 1990, pp. 505-513.
"Nuclear Relaxation of Human Brain Gray and White Matter: Analysis of Field Dependence and Implications for MRI" Helmut W. Fisher et al., Magnetic Resonance in Medicine 16, 317-334 (1990).
"Are Hepatic and Muscle T.sub.2 Values Different at 0.5 and 1.5 Tesla?" Magnetic Resonance Imaging, vol. 7, pp. 363-367, 1989, Michael E. Bernardino et al.
"Biological Significance of Iron-Related Magnetic Resonance Imaging Changes in the Brain" Arch Neurol-vol. 49, Jul. 1992, Jesus Pujol, M.D. et al.
"Transverse Relaxation of Solvent Protons Induced by Mangetized Spheres: Application to Ferritin, Erythrocytes, and Magnetite" Pierre Gillis et al. Magnetic Resonance in Medicine 5, 323-345 (1987).
"MR Imaging of Intracerebral Blood: Diversity in the Temporal Pattern at 0.5 1.0T" Amer Zyed et al., AJNR 12:469-474, May/Jun. 1991;AJR 157:133-138 Jul. 1991.
"NMR Relaxation Times of Blood: Dependence on Field Strength, Oxidation State, and Cell Integrity" John M. Gomori et al., J Comput Assit Tomogr, vol. 11, No. 4 1987, pp. 684-690.
"Does signal-attenuation on high-field T.sub.2 -weighted MRI of the brain reflect regional cerebral iron deposition? Observations on the relationship between regional cerebral water proton T.sub.2 values and iron levels" D. J. Brooks et al., Journal of Neurology, Neurosurgery, and Psychiatry 1989; 52:108-111.
"Notes On the Origin of Paramagnetic Inhomogeneity Effects in Whole Blood" N. A. Watwiyoff et al., Magnetic Resonance in Medicine 20, 144-150 (1991).
"T.sub.2 Estimates in Healthy and Diseased Brain Tissue: A Comparison Using Various MR Pulse Sequences.sup.1 " Robert H. Darwin et al., Radiology 1986;160:375-381.
"Reproducibility of Relaxation and Spin-Density Parameters in Phantoms and the Human Brain Measured by MR Imaging at 1.5T" Robert K. Breger et al., Magnetic Resonance in Medicine 3, 649-662 (1986).
"In-vivo Measurements of MRI Tissue Parameters at Various Magnetic Field Strengths" By Jyh-Horng Chen, Dissertation, Univ. of Calif. Berkeley with San Francisco (1991).
"MR Imaging of Cerebral Hematomas at Different Field Strengths: Theory and Applications" Rodney A. Brooks et al., J. Cpmput Assist Tomogr vol. 13 No. 2 1989 pp. 194-206.
"Hepatic Iron Overload: Quantitive MR Imaging.sup.1 " John M. Gomori et al., Radiology 1991;179;367-369.
"The Role of Ferritin and Hemosiderin in the MR Appearance of Cerebral Hemorrhage: A Histopathologic Biochemical Study in Rats" Keith R. Thulborn et al., AJNR 11:291-297, Mar./Apr. 1990; AJR 154:May 1990.
"Diffusion-Weighted MR Imaging of Acute Stroke: Correlation with T.sub.2 -Weighted and Magnetic Susceptibility-Enhanced MR Imaging in Cats" M. E. Moseley et al., AJNR 11:423-429, May/Jun. 1990.
"Late Onset Familial Hallervorden-Spatz Disease: MR Findings in Two Sisters" Paolo Ambrosetto, et al., AJNR 13:394-396, Jan/Feb 1992 1095-6108/92/1301-0394 .COPYRGT.American Society of Neuroradiology.
"MR Imaging of Parkinson Disease with Spin-Echo and Gradient-Echo Sequences" Bruce H. Braffman.sup.1.2, AJR 152:159-165, Jan. 1989.
"Brain Iron in Patients with Parkinson Disease: MR Visualization Using Gradient Modification" Joseph F. Norfray.sup.1 et al., AJNR 9:237-240, Mar./Apr. 1988.
"Study of Movement Disorders and Brain Iron by MR" J. Neal Rutledge.sup.1.2 et al., AJNR 8:397-411, May/Jun. 1987.
"Magnetic Resonance Imaging in Huntington Disease" J. Thayer Simmons et al., AJNR 7:25-28, Jan./Feb. 1986.
"Mechanisms of MR Signal Alteration by Acute Intracerebral Blood: Old Concepts New Theories" L. Anne Hayman et al., AJNR 12:899-907, Sep./Oct. 1991.
"Detection of Acute Intracerebral Hemorrhage on MR Imaging: Ineffectiveness of Prolonged Interecho Interval Pulse Sequences" Weingarten et al., AJNR 12:475-479, May/Jun. 1991.
"Clinically Documented Hemorrhage in Cerebral Arteriovenous Malfunctions: MR Characteristics" Phylliss M. Chappell et al., Radiology 1992; 183:719-724.
"Parkinson Plus Syndrome: Diagnosis Using High Field MR Imaging of Brain Iron" Burton P. Drayer et al., Radiology 1986; 159:493-498.
"Imaging of the Aging Brain Part II. Pathologic Conditions.sup.1 " Burton P. Drayer, MD, Radiology 1988; 166:797-806.
"Imaging of the Aging Brain Part I. Normal Findings.sup.1 " Burton P. Drayer, MD, Radiology 1988; 166:785-796.
"Wilson Disease of the Brain: MR Imaging.sup.1 " Alex M. Aisen et al., Radiology 1985; 157:137-141.
"Multiple System Atrophy (Shy-Drager Syndrome): MR Imaging.sup.1 " Behram Pastakia et al., Radiology 1986; 159:499-502.
.cent.Mangetic Resonance Imaging of Transfusional Hemosiderosis Complicating Thalassemia Major.sup.1 " Robert C. Brasch et al., Radiology 1984; 150:767-771.
"Intracranial Hematomas: Imaging by High-Field MR.sup.1 " John M. Comori, et al., Radiology 1985; 157:87-93.
"Magnetic Resonance Imaging of the Midbrain in Parkinson's Disease" J. R. Duguid et al., Annals of Neurology vol. 20 No. 6 Dec. 1986, pp. 744-747.
"Nuclear Magnetic Resonance Imaging in Movement Disorders" Steven A. Lukes, et al, Annals of Neurology vol. 13 No. 6 Jun. 1983 pp. 690-691.
"High-Field MR Imaging of Superficial Siderosis of the Central Nervous System" John M. Gomori et al., J Comput Assist Tomogr vol. 9 No. 5 1985 pp. 972-975.
"Brain Iron in Progressive Supranuclear Palsy: Clinical, Magnetic Resonance Imaging . . . " C. Edward Coffey et al., Journal of Neuropsychiatry vol. 1 No. 4 Fall 1989.
"MRI in autonomic failure" Robert T. Brown et al., Journal of Neurology, Neurosurgery and Psychiatry 1987; 50:913-914.
"Magnetic Resonance Imaging of Dystonic States" J. Neal Rutledge et al., Advances in Neurology, vol. 50 pp. 265-275 (1988)
Bartzokis George
Phelan Carolanne K.
Dawes Daniel L.
Hollinden Gary E.
Hollrah Glennon H.
The Regents of the University of California
LandOfFree
Method for quantitatively measuring and mapping stored iron in t does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for quantitatively measuring and mapping stored iron in t, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for quantitatively measuring and mapping stored iron in t will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2219440