Compounds for preparing modified hemoglobin

Details Compounds for preparing modified hemoglobin Compounds for preparing modified hemoglobin

1999-03-22

2000-06-06

Woodward, Michael P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 1, 560 18, 560 27, 560 34, 560 53, 560 64, 530380, 530385, 530829, 514 6, 514832, C07C 6976, A61K 3514, A61K 3816

Patent

active

060720727

ABSTRACT:
The present invention provides a chemically modified form of hemoglobin that is stabilized and can efficiently bind and release oxygen. In addition the chemically modified hemoglobin may be polymerized to increase its molecular weight and increase its stability so that it will have a longer half life in the circulatory system and may be used as a stable oxygen transport mediator which is useful as the basis of a blood substitute.

REFERENCES:
patent: 5268500 (1993-12-01), Lalezari et al.
patent: 5290803 (1994-03-01), Abraham et al.
patent: 5432191 (1995-07-01), Abraham et al.
patent: 5827888 (1998-10-01), Abraham et al.

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