Phenylenediamine derivative radical scavenger, brain-infarction

Details Phenylenediamine derivative radical scavenger, brain-infarction Phenylenediamine derivative radical scavenger, brain-infarction

1998-06-16

2000-06-06

Jones, Dwayne C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

A01N 3718

Patent

active

060719680

ABSTRACT:
A radical scavenger in accordance with the present invention comprises, as an effective ingredient, a phenylenediamine derivative or a pharmacologically acceptable salt thereof expressed by the following formula 1: ##STR1## wherein R.sub.1 represents a lower alkyl group; and each of R.sub.2 and R.sub.3 represents a hydrogen atom, an alkyl group having 1-10 carbon atoms, an alkenyl group having 1-10 carbon atoms, or benzyl group.
The phenylenediamine derivative above mentioned, as a radical scavenger, has a lipid peroxidation inhibitory activity so as to be available for inhibiting brain infarction or brain edema.

REFERENCES:
Passage from EP 474,403 A1 of Background Section on p. 2, lines 43-45, of CA: 74:96312e of 1971.
Shiseido Co Ltd., Abstract, Jap. Patent Application 07344947, Jun. 17, 1997.
Abstract of Nishino et al., of Jp 09143136 A2, Jun. 3, 1997.
Klosa, J. Praket. Chem. 19(4), 45-55(1963) (With Chemical Abstract 11349), German language.
Gupta,, Gupta, Search for New Local Anaesthetics. Part IV, English Language, J. Indian Chem. Soc. 34.528-530(1957).
Hassner et al., Synthetic Methods. Part 23 Rearrangement of Some Hydroxamic Acids Into Amides. A Self-Condensation Leading to Disproportionation English Language, J. Chem. Soc. Perkin. Trans. 733-737(1988).
Shiseido Co., Ltd., Abstract, Jap. Patent Application 07344947, Jun. 17, 1997.

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