Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1998-10-28
2000-06-06
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
A61K 3170
Patent
active
060718846
ABSTRACT:
The present invention relates to a method for the treatment of thrombocytopenia wherein an effective amount of a compound represented by the formula (A) is administered to a patient: wherein R.sub.2 represents H or OH, X is an integer of 0-26 or R represents --(CH.sub.2).sub.7 CH.dbd.CH(CH.sub.2).sub.7 CH.sub.3, and R.sub.1 is a substituent defined by the following (a) to (d):
REFERENCES:
patent: 4598051 (1986-07-01), Papahadjopolous
patent: 4728641 (1988-03-01), Tubaro
patent: 4806466 (1989-02-01), Papahadjopolous
patent: 4816450 (1989-03-01), Bell
patent: 4831021 (1989-05-01), Tubaro
patent: 4859769 (1989-08-01), Karlsson
patent: 4937232 (1990-06-01), Bell
patent: 4952683 (1990-08-01), Tschannen
patent: 5026557 (1991-06-01), Estis
patent: 5028715 (1991-07-01), Lyle
patent: 5041441 (1991-08-01), Radin
patent: 5073533 (1991-12-01), Marshall
patent: 5210073 (1993-05-01), Yodoi
K. Munesada, et al. Chem. Soc. Perkin Trans., 1991 pp. 189-194.
Higuchi, R., et al. "Structure and Biological Activity of Ganglioside Molecular Species" Liebigs Annalen de Chemie, vol. 1993, No. 4, Apr. 1993, pp. 359-366.
Nishizuka, Y. Science 233, 305-312 (1986).
Kaibuchi, K., et al. J. Biol. Chem. 260:1366-1369 (1985).
Crabtree. G.R. Science, 243:355-361 (1989).
Wepsic, T.H. Immunopharmacology and Immunotoxicology, vol. 11, 81-99 (1989).
Sweeley, Charles C. "Spingolipids" New Comprehensive Biochemistry, vol. 20, ed. Dennis E. Vance, 327-361 (1991).
E.G. Bremer, The Journal of Biological Chemistry, 261, 2434-2440 (1986).
Makita, et al. "Glycosphingolipids" New Comprehensive Biochemistry, vol. 10, pp. 1-99 (1985).
Zubaay, G. Biochemistry pp. 527-535, 1983.
Dillmman, R.O. "Phase I . . . " Mo. Biother., 1992, vol. 4, 117-121.
Dyaatlovitskaya, et al. Biokhi,iya, 49(3), 1984, pp. 432-436, including English Abstract.
Stutts, C.L..M. et at. Methods in Enzymology, vol. 179, Complex Carbohydrates, ed. Victor Ginsburg, vol. 179, 167-214 (1989).
Machler, B.A. Methods of Enzymology--Complex Carbohydrates, vol. L, ed. Victor Ginsburg, pp. 236-250 (1978).
Sweeley, et al. "Chemistry of Mammalian Glycolipids" The Glycoconjugates, vol. 1, pp. 459-540 (1977).
Sen-itiroh HaKomori "Chemistry of Glycosphingolipids" Handbook of Lipid Research, vol. 3, ed. Julian Kanfer, pp. 1-165 (1983).
Yu, Robert K., et al. Structure and Localization of Gangliosides. Neurobilogy of Gycoconjugates, ed. by Richard U. Margolis, pp. 1-42 (1989).
Hirsch, S., et al., "New Glycosphingolipids from Marine Organisms" Tetrahedron, vol. 45, No. 12 (1989), pp. 3897-3906.
Radin, et al. Biochemical Pharmacology 37(15):2879-2886 (1988).
Kalisiak, et al. Int. J. Cancer 49:837-845 (1991).
Wiegand, et al. Chemical Abstracts 114:122965M (1991).
Uchida, et al.; J. Biochem. 887:1843-1849 (1980).
Inokuchi, et al. Cancer Letters, 38:23-30 (1987).
R.J. Robb, The Journal of Immunology, vol. 136, 971-976 (1986).
Koike, et al. Carbohydrate Research, vol. 162, No. 2, pp. 237-246, May 1, 1987.
Costello, et al. ACS Symposium Series: Gel Surface Glycolycide, vol. 128, pp. 35-54, 1980.
Higuchi, R., et al. "Structures of Three New Cerebrosides . . . " Liebigs Ann Chem., 1990, 658-663.
Higuchi, R., et al. "Isolation and Characterization . . . " Liebigs Ann. Chem. 1990, 51-55.
Suglyama, S., et al. "Biologically Active Glycosides . . . " Liebigs Annalen de Chemie; 1991, No. 4, pp. 349-356; (04.04.91).
Schmidt, R. R., et al. "Synthesis of D-ribo-and L-lyxo-Phytosphinosi Carbohydrate Research"; vol. 174, (1988) pp. 169-179.
Sato, K., et al. "High Performance Tandem . . . " Anal. Chem. 1987, 59, 1652-1659.
Kawano, Y., et al. "Isolation and Structure . . . " Liebigs Ann Chem. 1988, 19-24.
Singh, B. N., et al. "Tegument Galactosylceramides . . . " Molecular and Biochemical Parasitolgoy, 26 (1987) 99-112.
Hannun, Y. A. "Functions of Sphingolipids . . . " Science, vol. 24-3, pp. 500-507 (1-1989).
Carroll, F. I., et al. J. Med. Chem. 1990, 33:2501-2508.
Ende, N. Life Sciences vol. 51, pp. 1249-1253, 1992.
Motokol, et al. Bioorganic & Medicinal Chemistry Letters, vol. 5, No. 22, pp. 2413-2416, 1995.
Honda, M. et al. "Synthesis of a New . . . "Chem. Pharm. Bull. vol. 39(8) pp. 1285-1391 (1991).
Isobe, R. et al. Biomedical and Environmental Mass Spectrometry vol. 13, pp. 585-594 (1986).
Tsunematsu, H. et al. Biochemical and Biophysical Research Communications vol. 146, No. 2; pp. 907-911 (1987).
Komori, Ti et al. Mass Spectrometry Reviews, 1985, 4, pp. 255-293.
Kalechmaan, Y. et al. The Journal of Immunology vol. 145, pp. 1512-157, Sep. 1, 1990.
Hall, E.J., Radiobiology for the Radiologist, 1978, pp. 3-12, 173-175, 205-215.
Tanikawa, S. et al. Blood, vol. 76 No. 3, Aug. 1, 1990, pp. 445-449.
Okana, A. et al. Transplantation vol. 47, No. 4, pp. 738-740, 1989.
Tamura, M. et al Transplantation vol. 51, No. 6, pp. 1166-1170, 1991.
Atkinson, K. et al, Blood, vol. 77 No. 6, Mar. 15, 1991, pp. 1376-1382.
Kodo, H. et al, The Lancet, Jul. 2, 1988, pp. 38-39.
Blazar, B. et al Blood, vol. 74, No. 6, Nov. 1, 1989 pp. 2264-2269.
Sheridan, W. P. et al. The Lancet, Oct. 14, 1989, pp. 891-895.
Brandt, S.J. The New England Journal of Medicine, vol. 318, Apr. 7, 1988, pp. 869-876.
Teshima, H. Exp. Hematol, vol. 17, 1989, pp. 853-858, Apr. 4, 1986.
Souza, L..M. et al Science vol. 232 pp. 61-65.
Nienhaus, A.W. The Journal of Clinical Investigation, vol. 8, Aug. 1987, pp. 573-577.
Monroy, R.L. Blood, vol. 70, No. 5, Nov. 1987, pp. 1696-1699.
Shiio, T. Jpn. J. Cancer Chemother. 15(3) Mar. 1988, pp. 481-485.
Taguchi, T. Jpn. J. Cancer Chemother., 12(2) Feb. 1985 pp. 366-378.
Kabaya Koji
Koezuka Yasuhiko
Motoki Kazuhiro
Kirin Beer Kabushiki Kaisha
Reamer James H.
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