PIGRL-1, a member of immunoglobulin gene superfamily

Details PIGRL-1, a member of immunoglobulin gene superfamily PIGRL-1, a member of immunoglobulin gene superfamily

1997-10-30

2000-09-05

Schwadron, Ronald B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 232, 536 2353, 536 2351, 536 234, 4353201, 435325, 4352523, 435243, C07H 2102, C07H 2104, C12N 510, C12N 1512

Patent

active

061145157

ABSTRACT:
PIGRL-1 polypeptide and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PIGRL-1 polypeptide and polynucleotides in the design of protocols for the treatment of Hyper-IgM Immunodeficiency (HIM), X-linked Severe Combined Immunodeficiency (XSCID), and IgA deficiency (IgA-D), among others and diagnostic assays for such conditions.

REFERENCES:
Ngo et al. "Chapter 14" from "The Protein Folding Problem and Tertiary Structure Predictions" Ed. Merz, Jr. et al., Birkhauser, 1994, pp. 491-495.
Hillier et al., Genebank Accession WO1276, NID g1273256, EST Apr. 18, 1996.
GenBank Accession #U06431, May 26, 1995.
GenBank Accession #AA509857, Jul. 8, 1997.
Piskurich, J.F. et al., "Molecular Cloning of the Mouse Polymeric Ig Receptor", J. Immunol. 154:1735-1747 (1995).
Krajci, P. et al., "Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor)", Eur. J. Immunol., 22:2309-2315 (1992).

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