Method and composition for the therapeutic and prophylactic trea

Details Method and composition for the therapeutic and prophylactic trea Method and composition for the therapeutic and prophylactic trea

1985-08-02

1987-03-31

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 39, 514157, 514213, 514221, 514223, 514224, 514263, 514323, 514327, 514602, 514648, A61K 3700, A61K 3154

Patent

active

046543236

ABSTRACT:
A novel method and composition are disclosed for the therapeutic and prophylatic treatment of trauma to the skin. In particular, burns, sunburn and frostbite are treated with compounds that have the ability to interfere with the action of calcium calmodulin complex. A preferred compound is trifluoperazine.

REFERENCES:
patent: 4443446 (1984-04-01), Cormier
Physicians Desk Reference (PDR) 26th ed., pp. 1292-1293 (1972).
Bibi, et al.-Acquired Local Resistance to Burns, Burns, 9, 387-393 (1983).
Chih-Chun et al.-Treatment of Burns, Shanghai Scientific & Technical Pub. (1982), pp. 31-38 & 263-265.
Hidada et al., Biopharmacological Assessment of Calmodulin Function; Utility of Calmodulin Antagonists, Reproduced in Calmodulin and Intracellular Ca.sup.++ Receptors, Kakuichi et al., 1983.
Levin et al., Molecular Pharmacology, 12, 581-589 (1976).

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