Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1992-07-09
1995-01-03
Moezie, F. T.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530412, 530826, 530824, 530825, 4241891, 4242281, 930 10, C07K 1300
Patent
active
053788141
ABSTRACT:
The entire genome of the hepatitis D virus has been shown to be a circular single-stranded RNA of 1679 bases. Several open reading frames in both the genomic and complementary strands indicate possible protein products. The products encoded in one open reading frame. ORF5, are identified as vital polypeptides p24.sup..delta. and p27.sup..delta., of which the nuclear .delta. antigens in HDV infected liver is comprised. These products, as well as others encoded in ORFs 1, 2, 6, and 7 are produced in recombinant expression systems. The ORF5 products, in particular, are useful for HDV diagnosis and vaccines.
REFERENCES:
patent: 4619896 (1986-10-01), Shattock
patent: 4708871 (1987-11-01), Geysen
patent: 4959462 (1990-09-01), Dijkema et al.
Kos et al., Nature (1986) 323(6088):558-560.
Rizzetto et al., J. Immunol. (1980) 125(1):318-324.
Wang et al., Nature (1986) 323(6088):508-518.
Wang et al., Nature, 323, 508-514, Oct.9-15, 1986.
Geysen et al., Proc. Natl. Acad. Sci., 81, 3998-4002, 1984.
Geysen et al., Molecular Immunology, 23, No. 7, 709-715, 1986.
Rizzetto et al., (1977) Gut 18:997-1003.
Rizzetto et al., (1980) Proc Natl Acad Sci (USA) 77:6124-6128.
Bonino et al., (1981) Hepatology 1:127-131.
Schiff et al., (1985) Diagnostic Medicine, pp. 17-22.
Jacobson et al., (1985) Hepatology 5:188-191.
Rizzetto et al., (1985) J. Hepatology 1:187-193.
Feinstone et al., Chem. Abstracts (1984) ref. 171213j.
Denniston et al., Science (1986) 232:873-875.
Valenzuela, Nature, 298, 347-350 (1982). "Synthesis and assembly of hepatitis B virus surface antigen particles in yeast".
Choo Qui-Lim
Houghton Michael
Overby Lacy R.
Wang Kang-Sheng
Weiner Amy J.
Chiron Corporation
McClung Barbara G.
Moezie F. T.
Robins Roberta L.
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