Long-acting local anesthetics

Details Long-acting local anesthetics Long-acting local anesthetics

1999-07-16

2000-09-05

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514646, A61K 31435, A61K 31135

Patent

active

061143448

ABSTRACT:
The subject invention concerns novel compounds that are useful as long-acting local anesthetics. The compounds are N-acyl derivatives of the compound known as tetracaine.

REFERENCES:
patent: 4562060 (1985-12-01), Broberg et al.
patent: 4618490 (1986-10-01), De Marco
patent: 5563153 (1996-10-01), Mueller et al.
patent: 5942543 (1999-08-01), Ernst
Wang, Ging Kuo, Marina Vladimirov, Hao Shi, Wai Man Mok, Johann G. Thalhammer, Douglas C. Anthony (1998) "Structure--Activity Relation of N-alkyl Tetracaine Derivatives as Neurolytic Agents for Sciatic Nerve Lesions" Anesthesiology 88(2):417-428.
Wang, G.K., M. Vladimirov, C. Quan, W.M. Mok, J.G. Thalhammer, D.C. Anthony (1996) "N-Butyl Tetracaine as a Neurolytic Agent for Ultralong Sciatic Nerve Block" Anesthesiology 85(6):1386-1394.
Buchi, J.X. and Perlia.(1971) In: Local Anesthetics vol. 1, International Encyclopedia of Pharmacology and Therapeutics, Sect. 8, Lechat, P., ed, Pergamon Press Ltd., Oxford, pp 39-130 (no copy is enclosed).

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