Vitamin D analogues

Details Vitamin D analogues Vitamin D analogues

1993-05-17

1995-01-03

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552653, C07C40100

Patent

active

053786955

ABSTRACT:
##STR1## The present invention relates to compounds of formula (I), in which formula R stands for an alkyl group containing from 7 to 12 carbon atoms optionally substituted with a hydroxy group; and derivatives of the compounds of formula (I) in which one or more hydroxy groups have been transformed into --O-acyl or --O-glycosyl or phosphate ester groups, such masked groups being hydrolyzable in vivo, in pure form or in mixtures. The present compounds find use in both the human and veterinary practice in the treatment and prophylaxis of autoimmune diseases, including diabetes mellitus, hypertension, inflammatory diseases such as rheumatoid arthritis and asthma as well as diseases characterized by abnormal cell differentiation and/or cell proliferation, and/or imbalance in the immune system.

REFERENCES:
Murayama, et al. "Synthetic studies of vitamin D.sub.3 analogues-VIII-Synthesis of 22-oxavitamin D.sub.3 analogues". Chem. Pharm. Bull. vol. 34, No. 10, pp. 4410-4413 (1986).
Abe, et al. "Synthetic analogues of vitamin D.sub.3 with an oxygen atom in the side chain skeleton" FEB 05407, vol. 226, No. 1, pp. 58-62 (Dec. 1987).
Chemical Abstracts, vol. 108, No. 11, Mar. 1988, Junko et al, "Synthetic Analogs of Vitamin D3 with an oxygen atom in the side chain skelton." see abstract 8819v, & FEBS Lett. 1987, 226 (1) 58-62.
Chemical Abstracts, vol. 110, No. 2, Jan. 1989, Katsuhito et al.: "Antitumor pharmaceuticals containing 9, 10-seco-5, 7, 10 (19)-pregnatriene derivatives." see abstracts 13599s & Jpn Kokai Tokkyo Koho JP 63107930, May 1988.

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