Detection of APC proteins

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 723, 436 63, 436 64, G01N 3353, G01N 33574, G01N 3348

Patent

active

061141240

ABSTRACT:
A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.

REFERENCES:
patent: 5098823 (1992-03-01), Bodmer et al.
patent: 5137806 (1992-08-01), LaMaistie et al.
Groden, et al., "Identification and Characterization of the Familial Adenomatous Polyposis Coli Gene", Cell, 66:589-600 (1991).
Joslyn, et al., "Identification of Delection Mutations and Three New Genes at the Familial Polyposis Locus", Cell, 66:601-613 (1991).
Kinzler, et al., "Identification of FAP Locus Genes From Chromosome 5q21", Science, 253:661-665 (1991).
Nishisho, et al., "Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients", Science, 253:665-669 (1991).
Orita, et al., Genomics, vol. 5, pp. 874-879, 1989.
Stanbridge, et al., "Identifying Tumor Suppressor Genes in Human Colorectal Cancer", Science, 247:12-13 (1990).
Fearon, et al., "Identification of a Chromosome 18q Gene That is Altered in Colorectal Cancer", Science, 247:49-56 (1990).
Baker et al., "Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas", Science, 244:217-221 (1989).
Bodmer et al., "Localization of the Gene for Familial Adenomatous Polyposis on Chromosome 5", Nature, 328:614-616 (1987).

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