Method of preparing a controlled-release pharmaceutical preparat

Details Method of preparing a controlled-release pharmaceutical preparat Method of preparing a controlled-release pharmaceutical preparat

1977-06-17

1979-03-20

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

252316, 424 25, 424 36, 424178, A61K 952, B01J 1302

Patent

active

041454103

ABSTRACT:
A method of preparing a controlled-release pharmaceutical compound for oral administration, which pharmaceutical compound is subject to enzymatic hydrolysis on oral administration, which method comprises encapsulating the pharmaceutical compound with a synthetic phosphatidyl compound having a modified polarhead moiety which increases the resistance of the phosphatidyl compound to phospholipase C hydrolysis.

REFERENCES:
patent: 4016100 (1977-04-01), Suzuki et al.
Gregoriadis: "The Carrier Potential of Liposomes in Biology and Medicine," New England J. Med. 295, 704-710, Sep. 23, 1976.

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