Functionalized nanocrystals and their use in detection systems

Details Functionalized nanocrystals and their use in detection systems Functionalized nanocrystals and their use in detection systems

1999-08-11

2000-09-05

Nutter, Nathan M.

Stock material or miscellaneous articles

Coated or structually defined flake, particle, cell, strand,...

Particulate matter

428404, 257 65, 257614, 257642, 424 91, 424 932, 424 936, 424 942, 424 96, 4272133, 427214, 427215, 427220, A61K 4900, B05D 700, B32B 900, B32B 904, H01L 2904

Patent

active

061140384

ABSTRACT:
Provided are compositions comprising water-soluble, functionalized nanocrystals. The water-soluble functionalized nanocrystals comprise quantum dots capped with a layer of a capping compound, and further comprise, by operably linking and in a successive manner, one or more additional compounds. The one or more additional compounds is comprised of at least a diaminocarboxylic acid which is operatively linked to the capping compound, and may further comprise an amino acid, an affinity ligand, or a combination thereof. Also provided are methods of using the functionalized nanocrystals having an affinity ligand to detect the presence or absence of a target substrate in a sample. The method comprises contacting the functionalized nanocrystals with the sample so that complexes are formed between the functionalized nanocrystals and substrate, if the substrate is present; exposing the complexes in the detection system to a wavelength of light suitable for exciting the functionalized nanocrystals of the complexes to emit a luminescence peak; and detecting the emitted luminescence peak.

REFERENCES:
patent: 5751018 (1998-05-01), Alivisatos et al.
Bruchez et al., Semiconductor Nanocrystals as Fluorescent Biological Labels; Science, Sep. 25, 1998, vol. 281:2013-2015.
Chan and Nie, Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection; Science, Sep. 25, 1998, vol. 281:2016-2018.
Quantum Dots meet Biomolecules; Sep. 28, 1998; C&EN; p. 8.

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