Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-

Details Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1- Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-

1979-08-17

1981-06-23

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

260239A, C07D47104

Patent

active

042752078

ABSTRACT:
Disclosed is a process for preparing 7-(1-hydroxethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and its pharmaceutically acceptable salts and esters (I) by total synthesis starting with L-aspartic acid and proceeding via intermediate II: ##STR1## R=blocking group

REFERENCES:
patent: 3923796 (1975-12-01), Rapoport
patent: 3950357 (1976-04-01), Kahan et al.
patent: 4123528 (1978-10-01), Cama et al.
patent: 4150156 (1979-04-01), Beattie et al.
patent: 4174316 (1979-11-01), Christensen et al.
Barash et al., Chem. Abst. 1977, vol. 87, No. 135049q & 135050.
Theilheimer, Synthetic Methods of Organic Chemistry, vol. 29, Karger, New York, 1975, No. 465.

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