Peptide macromolecular complexes

Details Peptide macromolecular complexes Peptide macromolecular complexes

1978-08-21

1981-06-23

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112B, 2601125R, 260121, 424 85, 424 87, 424 88, 424 92, 424177, 435188, A61K 39385, A61K 3944, C07G 700, C12N 996

Patent

active

042750008

ABSTRACT:
Macromolecular complexes which comprise a first and a second macromolecular moiety joined by a link derived from a linking agent having two or more reactive groups, one of these reactive groups being an activated acyl group, an isocyanate, an isothiocyanate, an iminoether, an iminothioether or an activated halogen atom attached to an aromatic ring and being capable of reacting with one of the macromolecules from which the macromolecular moieties are derived, under conditions where the remaining reactive group, or groups which is or are each an aziridine ring, an aryl azido group or a halogen atom in an .alpha.-position relative to a carbonyl group or two carbon atoms removed from a heteroatom carrying a lone pair of electrons, is or are substantially unreactive.
Methods are provided for making the complexes and so are uses for the complexes. Pharmaceutical formulations containing the complex as are provided.

REFERENCES:
patent: 3775253 (1973-11-01), Dieter et al.
patent: 3843447 (1974-10-01), Burkoth
patent: 3969287 (1976-07-01), Jaworek et al.
patent: 4007089 (1977-02-01), Smith
patent: 4029766 (1977-06-01), Helting
patent: 4066505 (1978-01-01), Schneider
patent: 4081329 (1978-03-01), Jaworek et al.
patent: 4096138 (1978-06-01), Scherr
patent: 4098645 (1978-07-01), Hartdegen et al.
patent: 4101380 (1978-07-01), Rubinstein et al.
patent: 4133949 (1979-01-01), Batz et al.
patent: 4172072 (1979-10-01), Ashmead
Thorpe et al., Nature, vol. 271 (Feb. 1978), pp. 752-755.

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