Standards for determining glycosylated hemoglobin

Compositions – Nonreactive analytical – testing – or indicating compositions

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23230B, 23909, 23913, 260112R, 260112B, 356 40, 356 42, 424 2, 424 3, G01N 3348, C09K 300

Patent

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042749786

ABSTRACT:
This invention encompasses a standard for determining glycosylated hemoglobin comprising a mixture of hemoglobin or methemoglobin and about 1% to 25% of the 2,4-dinitrophenyl derivative of hemoglobin or methemoglobin wherein a 2,4-dinitrophenyl group blocks the allosteric binding site of hemoglobin or methemoglobin.

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Currell, D., et al., Eur. J. Biochem., vol. 91, pp. 285-289 (1978).
Antonini, E., et al., "Hemoglobin and Myoglobin in Their Reactions with Ligands," North-Holland Publ. Co., Amsterdam, pp. 294-296 (1971).
Stevens, et al., J. Bio. Chem., vol. 252, No. 9, pp. 2998-3002 (1977).
Dolhofer, R., et al., Feas Letters, vol. 85, No. 1, pp. 86-90 (1978).
McDonald, M., et al., J. Bio. Chem., vol. 253, No. 7, pp. 2327-2332 (1978).

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