Process for the preparation of phenylacetic derivatives of thien

Details Process for the preparation of phenylacetic derivatives of thien Process for the preparation of phenylacetic derivatives of thien

1991-03-29

1993-02-23

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49504

Patent

active

051891700

ABSTRACT:
Compounds of formula: ##STR1## in which R.sub.1 and R.sub.2 are hydrogen or halogen, are prepared by reacting an aldehyde of formula: ##STR2## with CHBr.sub.3 and KOH in a mixture of an inert solvent and water. Further an ester of compound (I) wherein R.sub.1 is H and R.sub.2 is 2-Cl is reacted with 4,5,6,7-tetrahydrothieno[3,2-c]pyridine to produce a compound of formula III: ##STR3## which is useful as a medicament.

REFERENCES:
patent: 4529596 (1985-07-01), Aubert et al.
patent: 5036156 (1991-07-01), Bouisset et al.

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