Method of preparing pyridazinone derivatives

Details Method of preparing pyridazinone derivatives Method of preparing pyridazinone derivatives

1992-03-13

1993-02-23

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D23724

Patent

active

051891638

ABSTRACT:
A method for the preparation of a pyridazinone derivative having the general formula I: ##STR1## where: R.sup.1 is a phenyl group, optionally substituted, R.sup.2 is H, alkyl or carboxy, R.sup.3 is H, alkyl or alkoxy and R.sup.4 is alkyl; said method comprising reacting a hydrazone of glyoxylic acid halide having the formula VII: ##STR2## in which X is halogen, with an ester of formula VIII; ##STR3## in the presence of an alkaline earth base.

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von Dieter Seebach et al., Herstellung von 1,3 von 1,3-Diketonen under von Nitro-diketonen durch (1:1)-Acylierungen von Lithiumenolaten mit Acylchloriden, Helvetica Chimica Acta, vol. 64, (1981), pp. 716 and 718.
House, H. O. et al., The Chemistry of Carbanions, XXII, c-vs, O-Acylation of Metal Enola, J. Org. Chem., vol. 38 No. 3, 1973, pp. 514-515.

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