Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-01-30
1997-03-25
Trinh, Ba K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514283, 528421, 546 48, 546 51, 549510, 549511, A61K 31335, C07D30514
Patent
active
056145497
ABSTRACT:
Water-soluble prodrugs of the formula: ##STR1## wherein: D is a biologically active nucleophile;
REFERENCES:
patent: 4191380 (1978-07-01), Rubenstein et al.
patent: 4680338 (1987-07-01), Sundoro
patent: 4814470 (1989-03-01), Colin et al.
patent: 4942184 (1990-07-01), Haugwitz et al.
patent: 4943579 (1990-07-01), Vishnuvajjala et al.
patent: 4960790 (1990-10-01), Stella et al.
patent: 5004758 (1991-04-01), Boehm et al.
patent: 5015744 (1991-05-01), Holton
patent: 5019504 (1991-05-01), Christen et al.
patent: 5059699 (1991-10-01), Kingston et al.
patent: 5136060 (1992-08-01), Holton
patent: 5157049 (1992-10-01), Haugwitz et al.
patent: 5227400 (1993-07-01), Holton et al.
patent: 5229526 (1993-07-01), Holton
patent: 5272171 (1993-12-01), Ueda et al.
patent: 5278324 (1994-01-01), Kingston et al.
patent: 5342947 (1994-08-01), Lackey et al.
patent: 5352805 (1994-10-01), Kingston et al.
patent: 5362831 (1994-11-01), Mongelli et al.
patent: 5498729 (1996-03-01), Domb
Bioconjugate Chemistry Sep./Oct. 1992 vol. 3, No. 5; 351-362, Maeda, Hiroshi et al.
Journal of Bioactive and Compatible Polymers vol. 10- Jan. 1995, 51-66; Ohya, Yuichi et al.
Polymer Bulliten 18, 487-493 (1987) Gehrardt et al.
J. of Controlled Release 10, (1989) 145-154 Veronese, F et al.
Cancer Chemother Pharmacol (1992) 31 255-257 Waud, W. et al.
Biotechnology and Applied Biochemistry 9, 258-268 (1987) Buckn, A. et al.
J. Med. Chem, (1991), 34, 992-998, Francoise Gueritte-Voegelein, et al.
J. Org. Chem, (1986), 51, 797-802, Neil F. Magri, et al.
Journal of Medicinal Chemistry, (1973), vol. 16, No. 5, 573-574, Ben-Zion Weiner, et al.
Nature, vol. 364, 29 Jul. 1993, K.C. Nicolaou, et al.
Tetrahedron Letters, vol. 33, No. 36, pp. 5185-5188, 1992, A. Commercon, et al.
Proc. Int. Symp. Control. Release Bioact. Mater., 21 (1994), #1368, Yuichi Ohya, et al.
Cancer Treatment Reviews (1990), 17, 127-131, Terrence W. Doyle, et al.
Bioorganic & Medicinal Chemistry Letters, Vo. 4, No. 18, pp. 2223-2228 (1994) Shu-Hui Chen, et al.
Journal of Pharmaceutical Sciences, vol. 83, No. 4, Apr. 1994, Tetsuji Yamaoka, et al.
Bioorganic & Medicinal Chemistry Letters, vol. 4, No. 20, pp. 2465-2470, 1994, Richard B. Greenwald, et al.
Clinical Pharmacy, vol. 8, Apr. 1989, pp. 274-293, Ronald A. Fleming, et al.
Oncology, Dec. 1992, pp. 17-23, Michael J. Hawkins, et al.
Drug Design and Discovery, 1992, vol. 9, pp. 93-105, Tatsuro Ouchi, et al.
Eur. Polym. J., vol. 19, No. 12, pp. 1177-1183, S. Zalipsky, et al.
Angew. Chem. Int. Ed. Engl., 1994, 33, No. 1516, pp. 1583-1587, Kyriacos Costa Nicolaou, et al.
J. Med. Chem., 1992, 35, 145-151, Abraham E. Mathew, et al.
J. Med. Chem., 1981, 24, 622-625, R. Cecchi, et al.
"Novel, Water-Soluble Phosphate Derivatives of 2'-Ethoxycarbonyl Paclitaxel . . . ", Bioorganic & Medicinal Chemistry Letters, vol. 5, No. 3, pp. 247-252 (1995).
"Synthesis and Antitumor Evaluation of 2'-Oxycarbonyl Paclitaxel" Bioorganic & Medicinal Chemistry Letters, vol. 4, No. 15, pp. 1861-1864 (1994).
Greenwald Richard B.
Pendri Annapurna
Enzon Inc.
Mercanti Michael N.
Trinh Ba K.
LandOfFree
High molecular weight polymer-based prodrugs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with High molecular weight polymer-based prodrugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High molecular weight polymer-based prodrugs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2203847