Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1991-11-12
1993-02-23
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424430, 128832, A61F 614
Patent
active
051888351
ABSTRACT:
The invention concerns an intravaginal device comprising a combination of 17.beta.-estradiol and a supporting matrix for treating hypoestrogenic women. The device releases continously 17.beta.-estradiol at a rate of about 0.5 to about 25 .mu.g/24 h. The invention also comprises a method of preparing the device and a method of treating hypoestrogenic women by using the device.
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Maturitas vol. 3, 1981 pp. 125-133 Pharmacokinetics and pharmacodynamic effects of vaginal oestradiol administration from silastic rings in post-menopausal women.
Journ. Clinical Endocrinology vol. 54, No. 1, 1982, pp. 208-210 Development of a vaginal ring for achieving physioogic levels of 17 beta-estradiol in hypoestrogenic women.
Obstetrics & Gynecology, vol. 67, No. 1, 1986, pp. 91-94 (Stumpf) Selecting constant serum estradiol levels achieved by vaginal rings.
Andersson Sven-Borje
Lindskog Inga M.
Sjogren Bengt C. H.
Benston William E.
Kabi Pharmacia AB
Page Thurman K.
Philpitt Fred
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