Production of IBDV VP2 in highly immunogenic form

Details Production of IBDV VP2 in highly immunogenic form Production of IBDV VP2 in highly immunogenic form

1994-01-18

1997-03-25

Cunningham, Thomas M.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4241921, 4242041, 435 693, 4353201, 530395, 530403, 536 234, 536 2372, C12N 1581, C12N 1540, A61K 3912

Patent

active

056144091

ABSTRACT:
A highly immunogenic form of the VP2 structural protein of IBDV comprises a high molecular weight aggregated form of VP2 produced by the expression of a nucleotide sequence coding for the VP2 structural protein or a polypeptide displaying the antigenicity of all or a part of the VP2 structural protein in a yeast or other eukaryotic host cell.

REFERENCES:
patent: 4511652 (1985-04-01), Fogel et al.
patent: 4940661 (1990-07-01), Etcheverry et al.
patent: 5350575 (1994-09-01), Azad et al.
Jagadish, M.N. et al (1988) Yeast 4:S154.
Azad, A.A. et al. (1986) Virology 149:190-198.
Hudson, P.J. et al. (1986) Nucl. Acids Res. 14:5001-5012.
Fahey, K.J. et al. (1985) J. Gen. Virol. 66:2693-2702.
Miyajima, A. et al. (1985) Gene 37:155-161.
Azad, A. A., et al., Vaccines 90, pp. 59-62 (1990). "Full protection against an immunodepressive viral disease by a recombinant antigen produced in yeast".
Jagadish, M. N., et al., Gene 95:179-186 (1990), "Expression and characterization of infectious bursal viral disease virus polyprotein in yeast".
Hallewell, R. A., et al., Bio/Technology 5:363-366 (1987), "Amino terminal acetylation of authentic human Cu,Zn superoxide dismutase produced in yeast".
MacReadie, I. G., et al., Vaccine 8:549-552 (1990), "Passive protection against infectious bursal virus by viral VP2 expressed in yeast".

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