Process for the preparation of .beta.-phenylisoserine and its an

Details Process for the preparation of .beta.-phenylisoserine and its an Process for the preparation of .beta.-phenylisoserine and its an

1996-08-23

1998-06-09

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, C07D30514

Patent

active

057636281

ABSTRACT:
The present invention relates to new process for the preparation of .beta.-phenylisoserine and its analogues of general formula: ##STR1## which are particularly useful for preparing taxane derivatives which have remarkable antitumour and antileukaemic activities.

REFERENCES:
patent: 4924012 (1990-05-01), Colin et al.
patent: 5041643 (1991-08-01), Tinti et al.
patent: 5175315 (1992-12-01), Holton
patent: 5294737 (1994-03-01), Ojima
patent: 5304670 (1994-04-01), Correa et al.
I. Ojima et al., "Azetidines and Bisazetidines. Their Synthesis and Use as the Key Intermediates to Enantiomerically Pure Diamines, Amino Alcohols, and Polyamines", Journal of Organic Chemistry vol. 56, No. 18 (1991) pp. 5263-5277.
Palomo et al. "Highly Steroselective Synthesis of alpha-hydroxy beta-Amino acids through beta-Lactams: Application to the Synthesis of the Taxol and Bestatin Side Chains and Related Systems", Tetrahedron Letters, vol. 31, No. 44. pp. 6429-6432, 1990.

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