Process for preparing pyrimidine derivatives

Details Process for preparing pyrimidine derivatives Process for preparing pyrimidine derivatives

1996-02-05

1998-06-09

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544287, 544253, 544283, 544279, 544278, 544254, 544255, 544256, C07D23934, C07D23988

Patent

active

057636087

ABSTRACT:
The present invention provides a process for preparing a 5,6-dihydro-3H-pyrimidin-4-one derivatives which comprises the steps of (a) dehydrating a N-acyl beta amino acid in the presence of a dehydration agent and an organic solvent for a sufficient period of time and under suitable temperature and pressure conditions to form an oxazone (b) adding a carboxylic acid and a primary amine salt of a carboxylic acid to said oxazone to form a mixture, (c) distilling azeotropically said mixture for a suitable period of time and under suitable temperature and pressure conditions to substantially remove said dehydration agent and said organic solvent, and (d) heating the product of step (c) for a sufficient period of time and under suitable temperature and pressure conditions to form said pyrimidin derivatives.

REFERENCES:
Bormann, et al., Chem Ber., 1974, 107(1), pp. 270-277.

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