Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1995-05-12
1998-06-09
Acquah, Samuel A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514 78, 514171, 424 7805, A61K 31685
Patent
active
057634220
ABSTRACT:
Disclosed are compositions comprising non-steroid anti-inflammatory drugs (NSAID'S)complexed with zwitterionic or neutral phospholipids and having reduced gastrointestinal irritating effects and enhanced antipyretic analgesic, and antiinflammatory effects. Also disclosed are improved methods of using the complexes for treating fever, inflammation, and preventing platelet aggregation. In some embodiments, the anti-pyretic activity of sub-therapeutically used amounts of NSAID's are enhanced to elicit anti-pyretic activity in vivo when associated (noncovalently) with zwitterionic phospholipids, such as dipalmitoyl phosphatidyl choline.
REFERENCES:
patent: 4309420 (1982-01-01), Ghyczy et al.
patent: 4332795 (1982-06-01), Ghyczy et al.
patent: 4369182 (1983-01-01), Ghyczy et al.
patent: 4378354 (1983-03-01), Ghyczy et al.
patent: 4421747 (1983-12-01), Ghyczy et al.
patent: 4528193 (1985-07-01), Ghyczy et al.
patent: 4684632 (1987-08-01), Schulz et al.
patent: 4687766 (1987-08-01), Wendel et al.
patent: 5032585 (1991-07-01), Lichtenberger
Author unknown, "Press Digest for Nature Medicine," Nature Medicine, pp. 1-4, in particular, p. 2, Feb., 1995.
Dialog Search Report, pp. 1-66, dated Jan. 9, 1995, 2:03 p.m.
Dialog Search Report, pp. 1-6, dated Jan. 9, 1995, 3:19 p.m.
Dialog Search Report, pp. 1-24, dated Jan. 9, 1995, 3:50 p.m.
Dial, et al., "Gastroprotective Activity of Dietary Lipids," AGA Abstracts, pp. A61, Apr., 1992.
Go, et al., "Gastric Mucosal Hydrophobicity and Helicobacter Pylori: Absence of a Direct Relation?" AGA Abstracts, 102(4) (Part 2), Apr., 1992.
Lichtenberger, et al., "Chronic Elevation of Intraluminal Ammonia Induces Gastroduodenal (G-D) Hypertrophy and a Defect in the Mucosal Barrier," AGA Abstracts, Apr., 1992.
Lichtenberger, et al., "Ammonium (NH.sub.4+) Prevents the Denovo Formation of a Phospholipd (PL) Monolayer Surface: Is This the Basis of H. Pylori-Induced Reduction in Gastric Mucosal Hydrophobicity?" AGA Abstracts, pp. A653, Apr., 1992.
Lichtenberger, et al., "Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Associate with Zwitterionic Phospholipids: Insight Into the Mechanism and Reversal of NSAID-Induced Gastrointestinal Injury," Nature Medicine, 1(2):154-158, 1995.
Lichtenberger, et al., "ASA Forms An Ionic Complex With Phosphatidylcholine: Possible Molecular Explanation For Its Ulcergenic Action," Gastroenterology, vol. 104, No. 4, Part 2, A134, AGA Abstracts, 1993.
Lichtenberger, et al., "Certain NSAIDS Chemically Associate With Surface Phospholipids: Insight Into Mechanism And Reversal of NSAID-Induced Gastric Injury," Gastroenterology, vol. 106, A125, 1994.
Lichtenberger, et al., "NSAIDs complexed to phosphatidylcholine have reduced GI toxicity and enhanced bioavailability," Gastroenterology, vol. 108, No. 4, A149, 1995.
Lichtenberger, et al., "Effect of naproxen on gastric mucosal hydrophobicity: possible interaction with surface phospholipids," Gastroenterology, vol. 108, No. 4, A149, 1995.
Giraud, et al., "Zwitterionic phospholipids facilitate the transport of aspirin across artificial membranes," Gastroenterology, vol. 108, No. 4, A101, 1995.
Rhone-Poulenc Rorer, Nattermann Phospholipid GMBH, "1. Lecithin: Definitions and Descriptions," Phospholipids and Liposomes, published after 1990.
Clarke, et al., "Antinociceptive effects of non-steroidal anti-inflammatory drugs in a rat model of unilateral hindpaw inflammation," European Journal of Pharmacology 257 (1994) 103-108.
Glenn, et al., "Simple Laboratory Procedures for the Evaluation of Topically-Active Anti-Inflammatory Drugs," Agents and Actions, vol. 8/5 (1978) 497-503.
Davis, et al., "Processed Aloe vera Administered Topically Inhibits Inflammation," Journal of the American Podiatric Medical Association, vol. 79, No. 8 (Aug., 1989) 395-397.
Lichtenberger, et al, "Zwitterionic Phospholipids Enhance Aspirin's Therapeutic Activity, as Demonstrated in Rodent Model Systems," JPET, 277:1221-1227, 1996.
Butler Bruce D.
Lichtenberger Lenard M.
Acquah Samuel A.
Board of Regents , The University of Texas System
Mayfield Denise L.
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