DNA encoding a cytokine that induces apoptosis

Details DNA encoding a cytokine that induces apoptosis DNA encoding a cytokine that induces apoptosis

1996-06-25

1998-06-09

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 695, 4351723, 4352523, 4353201, 536 231, 536 235, 536 2431, C12N 1519, C07K 14525

Patent

active

057632235

ABSTRACT:
A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.

REFERENCES:
patent: 5512435 (1996-04-01), Renschler et al.
Bowie et al. (1990) Science vol. 247, pp. 1306-1310.
Smith et al., "The TNF Receptor Superfamily of Cellular and Viral Proteins: Activation, Costimulation, and Death," Cell 76:959-962, 1994.
Smith et al., "CD30 Antigen, A Marker for Hodgkin's Lymphoma, is a Receptor Whose Ligand Defines an Emerging Family of Cytokines with Homology to TNF," Cell 73:1349-1360, 1993.
Goodwin et al., "Molecular Cloning of a Ligand for the Inducible T Cell Gene 4-1BB: a Member of an Emerging Family of Cytokines with Homology to Tumor Necrosis Factor," Euro. J. Immunol. 23:2631-2641, 1993.
Suda et al., "Molecular Cloning and Expression of the Fas Ligand, a Novel Member of the Tumor Necrosis Factor Family," Cell 75:1169-1178, 1993.
Beutler and Huffel, "Unraveling Function in the TNF Ligand and Receptor Families," Science 264:667-668, 1994.
Banner et al., "Crystal Structure of the Soluble Human 55 kd TNF Receptor-Human TNF.beta. Complex: Implications for the TNF Receptor Activation," Cell 73:431-445, 1993.
Sachs and Lotem, "Control of Programmed Cell Death in Normal and Leukemic Cells: New Implications for Therapy," Blood 82:15-21, 1993.
Hollenbaugh et al., "Construction of Immunoglobulin Fusion Proteins," Current Protocols in Immunology, Supplement 4, 1992, pp. 10.19.1-10.19.11.
Landschulz et al., "The Leucine Zipper: a Hypothetical Structure Common to a New Class of DNA Binding Proteins," Science 240:1759-1764, 1988.
Hoppe et al., "A Parallel Three Stranded .alpha.-Helical Bundle at the Nucleation Site of Collagen Triple-Helix Formation," FEBS Letters 344:191-195, 1994.
Takeda et al., "A Molecular Inventory of Human Pancreatic Islets: Sequence Analysis of 1000 cDNA Clones," Human Molecular Genetics 2(11):1793-1798, 1993.
Wiley et al., "Identification and Characterization of a New Member of the TNF Family that Induces Apoptosis," Immunity 3:673-682, 1995.
Pitti et al., "Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family," J. Biol. Chem. 271(22):12687-12690, 1996.
O'Mahony et al., "An Immune Suppressive Factor Derived from Esophageal Squamous Carcinoma Induces Apoptosis in Normal and Transformed Cells of Lymphoid Lineage," J. Immunol. 151:4847-4856, 1993.
Kroemer, "The Pharmacology of T Cell Apoptosis," Advances in Immunology 58:211-296, 1995.
Takahashi et al., "Human Fas Ligand: Gene Structure, Chromosomal Location and Species Specificity," International Immunol. 6(10):1567-1574, 1994.
Wong et al., "Antiviral Properties of TNF," in Tumor Necrosis Factors: The Molecules and Their Emerging Role in Medicine, Raven Press, Ltd., New York, 1992, pp. 371-381.
Goodwin et al., "Study of the Stucture and Function of Trail, A New Member of the TNF Ligand Family," European Cytokine Network, 7(2):166, 1996.
Smith et al., "Trail: A New Member of the TNF Ligand Family That Induces Apoptosis," European Cytokine Network, 7(3);429, 1996.
Marsters et al., "Activation of Apoptosis by Apo-2 Ligand is Independent of FADD but Blocked by CrmA," Current Biology, 6(6):750, 1996.

Affiliated with

Also associated with

Rating

DNA encoding a cytokine that induces apoptosis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA encoding a cytokine that induces apoptosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding a cytokine that induces apoptosis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2197880