Oral delivery of vaccines using polymerized liposomes

Details Oral delivery of vaccines using polymerized liposomes Oral delivery of vaccines using polymerized liposomes

1997-01-17

1998-06-09

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

264 41, 264 43, 424 9321, 424 94, 424 951, 424 96, 4241841, 4242781, 424450, 424812, 4284022, A61K 9127, A61K 3900, A61M 3612

Patent

active

057629048

ABSTRACT:
Polymerized liposomes, methods of preparing the polymerized liposomes and incorporating biologically active substances within the polymerized liposomes, and methods of administering polymerized liposomes containing a biologically active substance to be delivered to a patient are disclosed. The polymerized liposomes are prepared by polymerizing double bond-containing liposomes. The polymerization can be initiated with a source of radiation and/or a free radical initiator. Biologically active substances can be incorporated into both the hydrophilic and hydrophobic layers of the liposomes, either during or after polymerization. The polymerized liposomes can be administered orally to a patient in need of the biologically active substance to be delivered. Examples demonstrate enhanced stability.

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