Polynucleotides encoding mammaglobin, a mammary-specific breast

Details Polynucleotides encoding mammaglobin, a mammary-specific breast Polynucleotides encoding mammaglobin, a mammary-specific breast

1995-05-31

1997-09-16

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2431, 536 231, C07H 2102, C07H 2104

Patent

active

056682670

ABSTRACT:
A purified and isolated DNA sequence and the encoded mammary-specific protein, mammaglobin, are disclosed. Also disclosed are methods for the detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin.

REFERENCES:
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Bjork et al., Expression and Partial Characterization of Estramustine-Binding Protein (EMBP) in Human Breast Cancer and malignant Melanoma, Anticancer Res 11:1173-82 (1991).
Miele et al., Uteroglobin: Structure, Molecular Biology, and New Perspectives on Its Function as a Phospholipase A.sub.2 Inhibitor, Endocrine Rev 8:474-90 (1987).
Cato et al., The Hormonal Regulation of Uteroglobin Gene Expression, Anticancer Res 5:65-72 (1985).
Parker et al., Organization and Expression of Genes Encoding Prostatic Steroid Binding Protein, Ann N Y Acad Sci 438:115-24 (1984).
Parker et al., Organization and Expression of Prostatic Steroid Binding Protein Genes, J. Steroid Biochem 20:67-71 (1984).
Parker et al. (1983) J. Biol. Chem 258:12-15.

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