Process for the enantioselective hydrogenation of ketosiophorone

Details Process for the enantioselective hydrogenation of ketosiophorone Process for the enantioselective hydrogenation of ketosiophorone

1995-06-08

1996-08-06

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

558260, 558276, 560106, 560162, 560259, C07C 6902, C07C 6976, C07C 6996, C07C27134

Patent

active

055435599

ABSTRACT:
The present invention is concerned with a process for the manufacture of optically active compounds of the formula ##STR1## wherein R signifies lower alkyl, lower alkoxy, phenyl, benzyl or --NR.sub.2.sup.1, R.sup.1 signifies lower alkyl, phenyl, benzyl or hydrogen and * signifies an optically active center, by asymmetrically hydrogenating an enol derivative of ketoisophorone of the formula ##STR2## wherein R has the significance given above, in the presence of a rhodium complex of an optically active diphosphine ligand.

REFERENCES:
Takaya et al, Catalytic Asymmetric Synthesis, pp. 1-36 month not available (1993).
Mayer, et al. Helevtica Chimica Acta, vol. 63, pp. 1451-1455, month not available (1980).
Brunner, et al. Journal of Organometallic Chemistry, vo. 456, pp. 71-75 month not available (1993).

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