Occlusion compound of 2-nitroxymethyl-6-chloropyridine with .bet

Details Occlusion compound of 2-nitroxymethyl-6-chloropyridine with .bet Occlusion compound of 2-nitroxymethyl-6-chloropyridine with .bet

1984-09-26

1986-03-11

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536103, C08B 3716, A61K 3173

Patent

active

045755485

ABSTRACT:
An occlusion compound of 2-nitroxymethyl-6-chloropyridine with .beta.-cyclodextrin is disclosed herein as well as a process for preparing the occlusion compound thereof. The occlusion compound of the present invention has a molar ratio of 2-nitroxymethyl-6-chloropyridine to .beta.-cyclodextrin of between about 1:1 and about 3:1. The present occlusion compound is nonvolatile, thereby overcoming the problems associated with the volatility of the 2-nitroxymethyl-6-chloropyridine for pharmacuetical preparations. The process of the present invention is carried out by reacting 2-nitroxymethyl-6-chloropyridine with .beta.-cyclodextrin either by kneading both compounds together with a small amount of a solvent or by mixing both compounds in an appropriate solvent, such as water. The occlusion compound is then precipitated, separated and further purified by conventional methods.

REFERENCES:
patent: 2959580 (1960-11-01), Schlenk et al.
patent: 3420788 (1969-01-01), Solms
patent: 4365061 (1982-12-01), Szejtli et al.
patent: 4425336 (1984-01-01), Tuttle
patent: 4482709 (1984-11-01), Iwao et al.
Dissertation Abstracts International, vol. 41, No. 6, Dec. 1980, p. 2127-B.

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