Bisamidine derivatives as thrombin inhibitors

Details Bisamidine derivatives as thrombin inhibitors Bisamidine derivatives as thrombin inhibitors

1992-12-23

1993-09-28

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142375, 514319, 540607, 544159, 546206, 546226, A61K 31535, A61K 3155, C07D21116, C07D295192

Patent

active

052486737

ABSTRACT:
The present invention provides new thrombin inhibiting bisamidines derivatives, their pharmaceutically acceptable salts and hydrates, methods for their preparation, pharmaceutical composition, a process for their preparation, and use of the compounds in treatment of thrombosis, ischemia and stroke.

REFERENCES:
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patent: 4374248 (1983-02-01), Crenshaw et al.
patent: 4440933 (1984-04-01), Montzka
patent: 4537896 (1985-08-01), Cleason et al.
John E. Starrett, Jr., et al., J. Med. Chem., 32: 2204 (1989).
Bajusz, et al., Int. J. Pept. Protein Res., 12: 217-221 (1978).

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