Process for separation of .alpha.substituted carboxylic acid ami

Details Process for separation of .alpha.substituted carboxylic acid ami Process for separation of .alpha.substituted carboxylic acid ami

1992-01-10

1993-09-28

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435136, 435822, 435824, C12P 1302

Patent

active

052486087

ABSTRACT:
Enzyme-catalysed preparation of an .alpha.-substituted optically active carboxylic acid, using enantioselective hydrolysis of a mixture of the enantiomers of the corresponding amide, an Ochrobactrum anthropi or an Klebsiella sp. being used as the enzyme. During the hydrolysis both the L-carboxylic acid and the remaining D-carboxylic acid amide are obtained with high optical purity and high yield, while the activity of the micro-organism is high. A large number of .alpha.-substituted carboxylic acid amides with a remarkable structural variety can be hydrolysed in this manner.

REFERENCES:
patent: 4443548 (1984-04-01), Oshima et al.
patent: 4481362 (1984-11-01), Nakai et al.
Asano Y, J. Biol Chem 264:14233-9 (1989),
Asano Y, BBRC 162:470-4 (1989),
ATCC Catalog pp. 112-113 (1989).
Chemical abstracts 105 (13), p. 555 Dec. 29, 1986, abstract No. 113629s.
Tetrahedron 45 (No 18, 1989), Pergamon Press (Oxford, GB) Y. Kato et al.: "First stereoselective synthesis of D-amino acid N-alkyl amide catalyzed by D-aminopeptidase"; pp. 5743-5754.

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