Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Patent
1994-09-06
1996-08-06
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
4241411, 4241421, 4241431, 4241451, 4241461, 4241931, 424806, A61K 39385, A61K 39395, A61K 3940, A61K 3942
Patent
active
055431437
ABSTRACT:
There is disclosed a method of treating a mammal infected with a macrophage pathogen comprising administering an effective amount of a TGF-.beta. antagonist. Macrophage pathogens include any pathogenic microorganism that replicates within macrophage cell hosts as their exclusive or primary host cells. TGF-.beta. antagonists include blocking antibodies specific for a human TGF-.beta., soluble TGF-.beta. receptors, protease inhibitors that inactivate a protease responsible for activating a precursor TGF-.beta. into an active, mature TGF-.beta., and combinations thereof.
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Corixa Corporation
Nutter Nathan M.
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