Diaminocyclobutene-3,4-diones

Details Diaminocyclobutene-3,4-diones Diaminocyclobutene-3,4-diones

1995-06-02

1996-06-25

Davis, Zinna Northington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

558414, C07C22520, A61K 31275

Patent

active

055300251

ABSTRACT:
The compounds of formula I: ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, alkyl or cyclic or bicyclic alkyl; R.sub.3 is formyl, alkanoyl, alkenoyl, alkylsulfonyl, aroyl, arylalkenoyl, arylsulfonyl arylalkanoyl or arylalkylsulfonyl; A is a substituted phenyl group of the following formula: ##STR2## wherein R.sub.5 is cyano and R.sub.6 is alkyl, chloro, bromo, fluoro or iodo and pharmaceutically acceptable salts thereof, are smooth muscle relaxants.

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E. Neuse et al., Liebigs Ann. Chem. 4:619-632 (1973).
Grunefeld et al., Arch Pharm., 318:1062-1070 (1985).
Takeno et al. Public Patent Disclosure Bulletin No. 6-92915, Apr. 5, 1994.

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