Substituted pyrimidinylaminothiazole derivatives useful as plate

Details Substituted pyrimidinylaminothiazole derivatives useful as plate Substituted pyrimidinylaminothiazole derivatives useful as plate

1993-12-22

1996-06-25

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544295, C07D27728, A61K 31425

Patent

active

055300006

ABSTRACT:
This invention relates to substituted thiazole derivatives of the following general formula, the substituent groups of which are as defined in the specification herein: ##STR1## These compounds are useful as inhibitors of platelet aggregation and inhibitors of adhesion molecules and may be provided in pharmaceutical compositions and in methods of treating reperfusion thrombosis injury in patients. Also included are novel intermediates for preparing the compounds of the invention.

REFERENCES:
patent: 4791200 (1988-12-01), Press
CA 111:96975, 1981.
CA 100:209516, 1981.
CA 95:25097, 1980.
Seko, Chem. Pharm. Bull. 39 651-657 (1991).
Singh, et al. Indian Journal of Chemistry (1983), 22B, 37-42.
Beyer, et al. Chem. Ber. (1962), 89, 893-901.

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