Use of selective ligands for treatment of disease states respons

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514617, A61K 3119, A61K 31165

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active

056681755

ABSTRACT:
In accordance with the present invention, there is provided a method for the treatment of subjects afflicted with steroid or steroid-like hormone-responsive disease states. The invention method comprises administering to the subject an effective amount of a ligand which selectively interacts with the receptor subtype associated with the steroid or steroid-like hormone-responsive disease state, wherein said ligand interacts with said receptor subtype to a significantly greater extent than with other subtypes of the same receptor class.

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Graupner et al., "6'-Substituted Naphthalene-2-Carboxylic Acid Analogs, A New Class Of Retinoic Acid Receptor Subtype-Specific Ligands" Biochemical and Biophysical Research Communications 179(3):1554-1561 (1991).
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Kakizuka et al., "Molecular Cloning and Characterization of Aberrant Retinoic Acid Receptors From A t(15;17) Positive Acute Promyelocytic Leukemia Patient", Journal of Cellular Biochemistry vol. Supplement No. 15G, p. 31 (Apr. 1991).
Lehmann et al., "Identification of Retinoids with Nuclear Receptor Subtype-selective Activities", Cancer Research 51:4804-4809 (1991).
Reynolds, J.E.F., "Martindale The Extra Pharmacopoeia" The Pharmaceutical Press, London, Acitretin, p. 916 (1989).

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