Compositions comprising ONCONASE(.TM.) and cisplatin, melphalan,

Details Compositions comprising ONCONASE(.TM.) and cisplatin, melphalan, Compositions comprising ONCONASE(.TM.) and cisplatin, melphalan,

1994-08-01

1996-06-25

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435199, 530350, 514 12, A61K 3843, C12N 922

Patent

active

055297757

ABSTRACT:
A pharmaceutical known by the trademark ONCONASE, as described in pending commonly owned application application Ser. No. 07/436,141 filed Nov. 13, 1989, is combined with drugs sold under the names cisplatin, Melphalan and Doxorubicin HCl. The combinations of ONCONASE with these drugs has unexpected bioactivity in vitro against OVCAR-3 human ovarian adenocarcinoma cells.

REFERENCES:
patent: 4882421 (1989-11-01), Shogen et al.
patent: 4888172 (1989-12-01), Szebenyi et al.
patent: 5175005 (1992-12-01), Fukushima et al.
Abstract (Dialog file 155 Accession No. 89146182) Legha, S. S. 1989, Semin Oncol. 16: 34-44.
Hird et al. 1990. Gener and Cancer, (P. Carney et al. eds.) John Wiley & Sons Ltd., N.Y.. pp. 184-189.
Ardelt et al. 1991. J. Biol. Chem. 266(1):245-251.
Mikulski et al. 1990. Cell Tissue Kinet. 23:237-246.

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