Piperidine derivatives and their use as therapeutic agents

Details Piperidine derivatives and their use as therapeutic agents Piperidine derivatives and their use as therapeutic agents

1995-08-04

1997-09-16

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514317, 514319, 514320, 514324, 546196, 546201, 546202, 546205, 546236, A61K 3140, A61K 31445, C07D40110, C07D40910

Patent

active

056681534

ABSTRACT:
Compounds of formula (I) ##STR1## exemplified by formulae (Ia) and (Ib) ##STR2## are tachykinin receptor antagonists useful in the treatment of disorders associated with the presence of an excess of tachykinins such as pain, inflammation, migraine, emesis and post herpetic neuralgia.

REFERENCES:
patent: 4859692 (1989-08-01), Berstein et al.
patent: 5270324 (1993-12-01), Zamboni et al.
Maggi et al. "Tachykinin receptors and tachykinin receptor antagonists" J. Auton. Pharmacol. v. 13, pp. 23-44 1993.

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