Trisubstituted benzene derivatives, composition and methods of t

Details Trisubstituted benzene derivatives, composition and methods of t Trisubstituted benzene derivatives, composition and methods of t

1991-09-11

1997-09-16

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514277, 514315, 514359, 514381, 514399, 514403, 514408, 514597, 514598, 544335, 544398, 544402, 544403, 546192, 546329, 546330, 564 48, 564 49, 564 51, 564 52, A61K 31495, A61K 31415, C07D24104, C07D23354

Patent

active

056681364

ABSTRACT:
A benzene, pyridine or pyrimidine derivative having the below shown formula is novel and useful as an anti-arteriosclerotic agent. ##STR1## wherein R.sup.1 stands for a lower alkyl group, an amino group which may be substituted, or the like; R.sup.2 stands for a group represented by the formula: ##STR2## (wherein R.sup.16 stands for an alkyl group having 1 to 6 carbon atoms, or the like) or the like; R.sup.3 stands for a group represented by the formula: --O--(CH.sub.2).sub.m --Y (Y stands for an imidazolyl or piperazinyl group, or the like and m is 1 to 6) or the like; R.sup.5 stands for a hydrogen atom, a lower alkyl group, or the like; A stands for a group represented by the formula: ##STR3## (wherein R.sup.6 stands for a hydrogen atom, a lower alkyl group, or the like), --N.dbd., or the like; and B stands for a group represented by the formula: ##STR4## (wherein R.sup.4 stands for a hydrogen or the like), --N.dbd., or the like.

REFERENCES:
patent: 3925387 (1975-12-01), Maruyama et al.
patent: 4623662 (1986-11-01), DeVries
patent: 4824843 (1989-04-01), Hoefle et al.
CA 77:88820, 1972.
Cross et al., J. Med. Chem. 28, 1427-1432, 1985.
Database WPI, Derwent Publications Ltd., London, GB AN 81-38689D & GB-A-2 062 622 (American Cyanamid Co., Week 8122, 1981.
Chemical Abstracts, No. 117176d, vol. 119, No. 11, Sep. 13, 1993 and J. Med. Chem., vol. 36, No. 11, 1993 (pp. 1630-1640).
J. Med. Chem., vol. 21, No. 10, 1989 (pp. 2318-2325).

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