Novel 1,3-benzodioxaneprostanoic acid derivatives and process fo

Details Novel 1,3-benzodioxaneprostanoic acid derivatives and process fo Novel 1,3-benzodioxaneprostanoic acid derivatives and process fo

1979-01-10

1980-08-12

Demers, Arthur P.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

2603403, 542426, 542429, 542430, C07D31908

Patent

active

042173604

ABSTRACT:
1,3-Benzodioxaneprostanoic acid compound of the formula ##STR1## wherein R.sub.1 is hydroxy, alkoxy of 1-10 carbon atoms, methylsulfamido, substituted or unsubstituted aryloxy, or O--CH.sub.2 --U--V wherein U is a direct bond, carbonyl, or carbonyloxy, and V is phenyl or phenyl substituted, e.g. by one or more of phenyl, phenoxy, alkoxy of 1-2 carbon atoms, and halogen; A is --CH.sub.2 --CH.sub.2 -- or trans --CH.dbd.CH--; B is --CH.sub.2 --CH.sub.2 -- or cis- or trans--CH.dbd.CH--; Z is hydroxymethylene or carbonyl; X Y, if Z is hydroxymethylene, is ##STR2## or, if Z is carbonyl, is ##STR3## or --CH.dbd.CH--; R.sub.2 is hydrogen or alkyl of 1-5 carbon atoms; R.sub.3 and R.sub.4 each are H, F, Cl, Br, I or CF.sub.3, CH.sub.3 or alkoxy of 1-2 carbon atoms or R.sub.3 and R.sub.4 in 6-,7-position is methylendioxy; and if R.sub.1 is hydroxy, salts thereof with pharmaceutically acceptable bases, are agents for inducing menstruation, interrupting pregnancy, inducing labor and synchronizing the sexual cycle in female mammals.

REFERENCES:
patent: 3956284 (1976-05-01), Hess et al.
patent: 3962218 (1976-06-01), Raduchel et al.
patent: 4000311 (1976-12-01), Gatzi et al.
patent: 4004020 (1977-01-01), Skuballa
patent: 4004021 (1977-01-01), Bowler et al.
patent: 4011242 (1977-03-01), Libit

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