Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-06-09
1995-08-15
Gupta, Yogendra N.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540481, 540547, A61K 3155, C07D26720, C07D28116
Patent
active
054419506
ABSTRACT:
The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
REFERENCES:
patent: 2852528 (1958-09-01), Hoffmann et al.
patent: 3210372 (1965-10-01), Werner et al.
patent: 3357998 (1967-12-01), Cusic et al.
patent: 3534019 (1970-10-01), Coyne et al.
patent: 3624104 (1971-11-01), Cusic et al.
patent: 3644346 (1972-02-01), Cusic et al.
patent: 3702852 (1972-11-01), Yale et al.
patent: 3917649 (1975-11-01), Mueller
patent: 3989719 (1976-11-01), Mueller
patent: 3992375 (1976-11-01), Mueller
patent: 4045442 (1977-08-01), Mueller
patent: 4125532 (1978-11-01), Mueller
patent: 4170593 (1979-10-01), Mueller
patent: 4290953 (1981-09-01), Koizumi et al.
patent: 4379150 (1983-04-01), Ito et al.
patent: 4559336 (1985-12-01), Mueller
patent: 4559337 (1985-12-01), Mueller
patent: 4614617 (1986-09-01), Mueller
patent: 4681939 (1904-07-01), Mueller
patent: 4704386 (1987-11-01), Mueller
patent: 5180720 (1993-01-01), Husa et al.
patent: 5182272 (1993-01-01), Hallinan et al.
patent: 5212169 (1993-05-01), Husa et al.
patent: 5225417 (1993-07-01), Dappen et al.
patent: 5281590 (1994-01-01), Husa et al.
patent: 5283240 (1994-02-01), Hallinan et al.
patent: 5288719 (1994-02-01), Husa et al.
patent: 5304644 (1994-04-01), Husa et al.
patent: 5324722 (1994-06-01), Hagen et al.
A. Bennett, et al. "Antagonism of Prostanoid-Induced Contractions of Rat Gastric Fundus Muscle by SC-19220 Sodium Meclofenamate, Indomethacin or Trimethoquinol," Br. J. Pharmac., 71, 169-175 (1980)-London.
W. E. Coyne, et al. "Anticonvulsant Semicarbazides," J. Med. Chem., 11(6), 1158-1160 (1968)-USA.
E. J. Drower, et al. "The Antiociceptive Effects of Prostaglandin Antagonists in the Rat," European Journal of Pharmacology, 133, 249-256 (1987)-Europe.
F. R. George, et al. "Antagonism of Alcohol Hypnosis by Blockade of Prostaglandin Synthesis and Activity: Genotype and Time Course Effects," Pharmacology, Biochemistry & Behavior, vol. 19, 131-136 (1983)-USA.
R. Gimet, et al. "Quantitative Determination of Polymorphic Forms in a Formulation Matrix Using the Near Infra-Red Reflectance Analysis Technique," Journal of Pharmaceutical & Biomedical Analysis, vol. 5, No. 3, 205-211 (1987)-Great Britain.
A. Gomes, et al. "Pharmacodynamics of Venom of the Centipede Scolopendra Subspinipes Dehaani," Indian Journal of Experimental Biology, vol. 20, 615-618, Aug. (1982)-India.
K. Gyires, et al. "The Use of the Writhing Test in Mice for Screening Different Types of Analgesics," Arch. Int. Pharmacodyn, 267, 131-140 (1984)-USA.
D. E. MacIntyre, et al. "Antagonism of Human Platelet Responses to Stimulatory and Inhibitory Prostaglandins," Prog. Lipid. Res., 20 (1-4), 453-9 (1981)-USA.
C. A. Maggi, et al. "The Effect of SC-19220, a Prostaglandin Antagonist, on the Micturition Reflex in Rats," European Journal of Pharmacology, 152, 273-279 (1988)-Europe.
K. Nagarajan, et al. "Synthesis of 10,11-Dihydrodibenz[b,f][1,4]oxazepine Derivatives as Potential Anticonvulsant & Psychotropic Agents," Indian Journal of Chemistry, vol. 24B, 840-844 (1985)-India.
S. Nakajyo, et al. "Inhibitory Effect of Bassianolide, a Cyclodepsipeptide, on Drug-Induced Contractions of Isolated Smooth Muscle Preparations," Japan J. Pharmacol., 32, 55-64 (1982)-Japan.
A. Rakovska, et al., "Antagonistic Effect of SC-19220 on the Responses of Guinea-Pig Gastric Muscles to Prostaglandins E.sub.1, E.sub.2, and F.sub.2.alpha.," Arch. Int. Pharmacodyn., 268, 59-69 (1984)-USA.
J. H. Sanner "Dibenzoxazepine Hydrazides as Prostaglandin Antagonists, " Intra-Science Chem. Rept., vol. 6, No. 1, 1-9 (1972)-USA.
J. H. Sanner, et al. "Structure-Activity Relationships of Some Dibenzoxazepine Derivatives as Prostaglandin Antagonists," Advances in the Biosciences, 9, 139-148 (1972)-USA.
Collins Joe T.
Hansen, Jr. Donald W.
Peterson Karen B.
Pitzele Barnett S.
Reitz David B.
G. D. Searle & Co.
Gupta Yogendra N.
Hastreiter Roberta L.
Williams Roger A.
LandOfFree
Substituted dibenzoxazepine and dibenzthiazepine carbamate compo does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted dibenzoxazepine and dibenzthiazepine carbamate compo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted dibenzoxazepine and dibenzthiazepine carbamate compo will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2181908